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Overall, the gut microbiota contributes to host metabolism not only by extracting nutrients, but also by producing signaling molecules that help coordinate metabolic regulation

5 KEY APPROACHES TO OVERCOME CHALLENGES IN PEPTIDE DELIVERY Protein engineering to resist enzymatic degradation Enzyme inhibitors and stabilizers for protection and stability PEGylation and albumin binding for half-life extension Enteric coatings for pH protection Encapsulation systems (eg, nanoparticles, liposomes) Permeation enhancers like SNAC Mucoadhesive systems for prolonged mucosal contact Several of these approaches are achieved by use of appropriate excipients